Nanostructured vanadium oxides are promising materials for applications as semiconductors, cathode materials in nanoelectronics, in sensor technology and heterogeneous catalysis. Despite the increasing number of publications on nanostructured vanadium oxides, there is still a significant lack of systematic studies focusing on molecular and supramolecular aspects of the material synthesis. In this article, we address the effect of hydrodynamic forces on vanadium oxide gelation and the formation of vanadium oxide lamellar phases and nanoscrolls systematically. Hydrodynamic forces were generated by circulating the reagent mixture in a closed loop. ESR spectra revealed that application of strong hydrodynamic forces resulted in increased V(4+) concentrations in the lamellar material. High V(4+) concentrations are crucial for the defined rolling up of the lamellar, amine-intercalated vanadium oxide layers during hydrothermal treatment to form the nanoscrolls. The electronic properties of the lamellar precursor which are translated into the final nanoscroll product can be controlled by hydrodynamics, thus enabling nanoscroll synthesis with defined physical characteristics and morphology.