Title: Quality assurance of multi­echo data used for myelin water mapping through residual bootstrapping
Authors: Billiet, Thibo
Dhollander, Thijs
Peeters, Ron
Maedler, Burkhard
Sunaert, Stefan
Emsell, Louise #
Issue Date: 2012
Conference: ESMRMB Annual Scientific Meeting edition:29 location:Lisbon date:4-6 October 2012
Article number: 243
Abstract: Myelin water mapping aims to quantify the myelin content within the brain using the short T2 time of
water trapped between myelin sheets. Multi-exponential fitting of the T2 decay can be used to derive
the myelin water fraction (MWF), a quantitative measure that can be applied to investigate myelin
change in neurodevelopment and disease. Investigations into the sensitivity of MWF to data quality
are limited. Here we demonstrate the influence of residuals on the MWF. These residuals are the fitting
error of the non-negative least square algorithm, which fits an exponential curve to the intensity decay
curve of multi-echo data. The aim is to obtain a visual representation of the influence of noise and
other external influences on the myelin mapping procedure.
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Translational MRI (+)
ESAT - PSI, Processing Speech and Images
# (joint) last author

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