Title: MicroRNAs Control the Maintenance of Thymic Epithelia and Their Competence for T Lineage Commitment and Thymocyte Selection
Authors: Zuklys, Saulius ×
Mayer, Carlos E
Zhanybekova, Saule
Stefanski, Heather E
Nusspaumer, Gretel
Gill, Jason
Barthlott, Thomas
Chappaz, Stephane
Nitta, Takeshi
Dooley, James
Nogales-Cadenas, Ruben
Takahama, Yousuke
Finke, Daniela
Liston, Adrian
Blazar, Bruce R
Pascual-Montano, Alberto
Holländer, Georg A #
Issue Date: Oct-2012
Publisher: American Association of Immunologists
Series Title: Journal of Immunology vol:189 issue:8 pages:3894-3904
Abstract: Thymic epithelial cells provide unique cues for the lifelong selection and differentiation of a repertoire of functionally diverse T cells. Rendered microRNA (miRNA) deficient, these stromal cells in the mouse lose their capacity to instruct the commitment of hematopoietic precursors to a T cell fate, to effect thymocyte positive selection, and to achieve promiscuous gene expression required for central tolerance induction. Over time, the microenvironment created by miRNA-deficient thymic epithelia assumes the cellular composition and structure of peripheral lymphoid tissue, where thympoiesis fails to be supported. These findings emphasize a global role for miRNA in the maintenance and function of the thymic epithelial cell scaffold and establish a novel mechanism how these cells control peripheral tissue Ag expression to prompt central immunological tolerance.
ISSN: 0022-1767
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity
× corresponding author
# (joint) last author

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