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29th International Coference on International Conference on Machine Learning, Date: 2012/06/26 - 2012/07/01, Location: Edinburgh

Publication date: 2012-01-01
Volume: 2012 Pages: 1287 - 1294
ISSN: 978-1-4503-1285-1
Publisher: Omnipress

ICML'12: Proceedings of the 29th International Coference on International Conference on Machine Learning

Author:

Davis, Jesse
Costa, Vítor Santos ; Peissig, Peggy ; Caldwell, Michael ; Berg, Elizabeth ; Page, David

Keywords:

Adverse drug events, Statistical relational learning, cs.LG, cs.AI, stat.ML

Abstract:

Learning from electronic medical records (EMR) is challenging due to their relational nature and the uncertain dependence between a patient's past and future health status. Statistical relational learning is a natural fit for analyzing EMRs but is less adept at handling their inherent latent structure, such as connections between related medications or diseases. One way to capture the latent structure is via a relational clustering of objects. We propose a novel approach that, instead of pre-clustering the objects, performs a demand-driven clustering during learning. We evaluate our algorithm on three real-world tasks where the goal is to use EMRs to predict whether a patient will have an adverse reaction to a medication. We find that our approach is more accurate than performing no clustering, pre-clustering, and using expert-constructed medical heterarchies.