Title: Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells
Authors: Chatterjee, Jayanta
Beullens, Monique
Sukackaite, Rasa
Qian, Junbin
Lesage, Bart
Hart, Darren J
Bollen, Mathieu ×
Köhn, Maja #
Issue Date: Oct-2012
Publisher: Wiley-VCH
Series Title: Angewandte Chemie - International Edition vol:51 issue:40 pages:10054-9
Abstract: The first cell-penetrating peptide that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach to study PP1 function and to counteract Ser/Thr kinase activity under pathologically increased kinase signaling.
ISSN: 1433-7851
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Biosignaling & Therapeutics
× corresponding author
# (joint) last author

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