Title: Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus
Authors: Kelleher, M R ×
McGuigan, C
Andrei, Graciela
Snoeck, Robert
De Clercq, Erik
Balzarini, Jan #
Issue Date: Jan-2005
Host Document: Nucleosides, nucleotides & nucleic acids vol:24 issue:5-7 pages:639-41
Conference: International Round Table on Nucleosides, Nucleotides and Nucleic Acids edition:XVIth location:Minneapolis, Minnesota, USA date:12-16 September 2004
Abstract: 2'3'-Dideoxy furanopyrimidines were shown to display anti-HCMV activity via a non-nucleoside mechanism. Further studies into highly modified sugar derivatives led to the preparation of N-and O-alkylated C10 furanopyrimidine analogues, and this work is described herein. These compounds were tested against HCMV strains, and the first case of submicromolar activity was observed.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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