Title: Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities
Authors: Ying, C ×
Holy, A
Hocková, D
Havlas, Z
De Clercq, Erik
Neyts, Johan #
Issue Date: Mar-2005
Publisher: American Society for Microbiology (ASM)
Series Title: Antimicrobial Agents and Chemotherapy vol:49 issue:3 pages:1177-1180
Abstract: Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.
ISSN: 0066-4804
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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