Title: A histological and mechanical study of aortic root support mesh after implantation in an ovine model
Authors: Verbrugghe, Peter ×
Verbelen, Tom
Verbeken, Erik
Pepper, John
Treasure, Tom
Meyns, Bart
Rega, Filip #
Issue Date: Aug-2012
Publisher: Wichtig Editore
Host Document: International Journal of Artificial Organs vol:35 issue:8 pages:559-559
Conference: European Society of Artificial Organs edition:39 location:Rostock date:26-29 September 2012
External aortic root support is being evaluated as an alternative to total root replacement for Marfan syndrome. In this way cardiopulmonary bypass and Bentall operation can be prevented. The hypothesis that graft material becomes incorporated in the adventitia was tested in a comparative study in lambs.

Graft material was wrapped around the carotid artery of six lambs. After a predefined 4-6 months implantation period the material was excised, histologically examined and stress tested.

We report on five lambs that grew from an average 16Kg to 27Kg, one animal died two weeks after implantation of pneumonia. Microscopy confirmed integrity of the vessel architecture within the sleeve. In one specimen there was mild oedema in the outer part of the media for less then 25% of the circumference. Other findings were consistent in all animals. Fibrosis was found for at least 50% of the adventitia. The lumen was normal but the vessel wall was significantly thickened. There was a significant increase in the maximum tensile strength of the supported segments (955 ± 372 N/cm2) compared to normal arterial tissue (188 ± 23 N/cm2).

Experimental limitations include the small numbers, necessary in a large animal experiment, but the findings were consistent and, we believe, representative of the biological response to external support. The external aortic root support mesh was well incorporated, the vessel wall was healthy, and its integrity preserved. Fibrosis of the tissue surrounding the adventitia and tensile force testing confirmed in this sheep model strengthening of the artery. There was no evidence of vessel wall thinning within the sleeve.
ISSN: 0391-3988
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Experimental Cardiac Surgery (-)
Translational Cell & Tissue Research
Cardiac Surgery
Department of Health and Technology - UC Leuven
× corresponding author
# (joint) last author

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