Title: Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications
Authors: Pérez-Pérez, María-Jesús ×
Priego, Eva-María
Hernández, Ana-Isabel
Camarasa, María-José
Balzarini, Jan
Liekens, Sandra #
Issue Date: Dec-2005
Publisher: Bentham Science Publishers
Series Title: Mini Reviews in Medicinal Chemistry vol:5 issue:12 pages:1113-1123
Abstract: Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. Moreover, TPase, identified also as the angiogenic platelet-derived endothelial cell growth factor (PD-ECGF), stimulates endothelial cell migration in vitro and angiogenesis in vivo and plays an important role in tumour progression and metastasis. Here we have summarized the most recent approaches in the search for novel TPase inhibitors together with the potential therapeutic applications of such inhibitors.
ISSN: 1389-5575
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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