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Title: Koorts van onbekende oorsprong: 40 jaar onderzoek in UZ leuven
Authors: Vanderschueren, Steven ×
De Munter, Paul
Blockmans, Daniel Engelbert
Bobbaers, Herman
Knockaert, Daniel #
Issue Date: 2012
Publisher: Nederlandstalige Medische Faculteiten in België
Series Title: Tijdschrift voor Geneeskunde vol:68 issue:17 pages:841-845
Abstract: Fever of unknown origin: 40 years of research in the University Hospital of Leuven
Fever of unknown origin (FUO) is currently defined as an illness of more than three weeks characterized by a high fever or a fever with an acute phase response and an uncertain diagnosis after a careful baseline investigation. Numerous disorders belonging to diverse sub specialties can present as such.
When dealing with FUO, lessons from the past are still pertinent. Thus, the “big three” diagnostic categories (not only infection, but also malignancy and sterile inflammation) should be kept in mind, pursuing all potential diagnostic clues.
In the search for a diagnosis behind FUO, atypical presentations of common diseases predominate over esoteric disorders. Thus, the threshold for taking samples for microbiological an pathological analyses should be kept low. Minimal invasive techniques are an asset. If the diagnosis remains uncertain, [(18F]fluoro-deoxyglucose positron emission tomography (FDG-PET° can be helpful. After a negative and careful evaluation, a watchful waiting approach can be adopted in selected patients in sable general health.
ISSN: 0371-683X
Publication status: published
KU Leuven publication type: AT
Appears in Collections:Laboratory for Clinical Infectious and Inflammatory Disorders
× corresponding author
# (joint) last author

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