Title: Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues
Authors: McGuigan, Christopher ×
Carangio, Antonella
Snoeck, Robert
Andrei, Graciela
De Clercq, Erik
Balzarini, Jan #
Issue Date: Jan-2004
Series Title: Nucleosides, nucleotides & nucleic acids vol:23 issue:1-2 pages:1-5
Abstract: The synthesis of 3'-fluoro analogues of recently discovered highly potent anti-VZV furanopyrimidine deoxynucleosides (BCNAs) is herein reported, for both the alkyl and alkylphenyl series. The compounds are tested against a range of herpes viruses and display poor activity, strongly supporting the notion of the importance of the presence of a 3'-OH for antiviral activity.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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