Title: Transduction of human MCP-3 by a parvoviral vector induces leukocyte infiltration and reduces growth of human cervical carcinoma cell xenografts
Authors: Wetzel, K ×
Menten, Patricia
Opdenakker, Ghislain
Van Damme, Jozef
Grone, HJ
Giese, N
Vecchi, A
Sozzani, S
Cornelis, JJ
Rommelaere, J
Dinsart, C #
Issue Date: Jul-2001
Publisher: John wiley & sons ltd
Series Title: Journal of gene medicine vol:3 issue:4 pages:326-37
Abstract: Background The oncosuppressive properties of some autonomous parvoviruses such as H-1 virus, together with their low pathogenicity, make them attractive vectors for tumor-directed gene therapy. Indeed, it was recently shown that these viruses became endowed with an enhanced oncosuppressive activity after they had been engineered to deliver a recognized therapeutic transgene. This prompted us to use a parvoviral vector to analyse the antineoplastic capacity of MCP-3 (monocyte chemotactic protein-3), a CC chemokine which has a broad spectrum of target cells, and can thus be considered to be a promising candidate for cancer treatment.
ISSN: 1099-498X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Immunobiology (Rega Institute)
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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