Title: Novel bicyclic sugar modified nucleosides: synthesis, conformational analysis and antiviral evaluation
Authors: Kifli, Nurolaini ×
Thet Htar, Thet
De Clercq, Erik
Balzarini, Jan
Simons, Claire #
Issue Date: Jun-2004
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:12 issue:12 pages:3247-3257
Abstract: Methodology previously described by us was applied to the formation of novel conformationally restrained bicyclic sugar modified nucleosides, with introduction of an oxazole and a thiocarbamate ring at the 2('),3(')-positions of the ribonucleosides. Two novel alkyl derivatives of 2('),3(')-dideoxy-2('),3(')-oxazole-beta-d-uridine and a novel uridine 2('),3(')-thiocarbamate were successfully synthesised. Conformational evaluation of all the synthesised compounds was conducted using the theoretical potential energy calculation via the macromodel v.6.0 molecular modelling programme. The conformationally restrained nucleosides described were evaluated against a wide range of DNA and RNA viruses. None of the compounds showed specific antiviral effects at subtoxic concentrations.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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