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Title: Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2
Authors: Kirchhoff, Tomas ×
Gaudet, Mia M
Antoniou, Antonis C
McGuffog, Lesley
Humphreys, Manjeet K
Dunning, Alison M
Bojesen, Stig E
Nordestgaard, Børge G
Flyger, Henrik
Kang, Daehee
Yoo, Keun-Young
Melin, Beatrice
von Wachenfeldt, Anna
HEBON
Hogervorst, Frans B L
Verheus, Martijn
Rookus, Matti A
Seynaeve, Caroline
Oldenburg, Rogier A
Ligtenberg, Marjolijn J
Ausems, Margreet G E M
Noh, Dong-Young
Aalfs, Cora M
Gille, Hans J P
Wijnen, Juul T
Gómez García, Encarna B
EMBRACE
Peock, Susan
Cook, Margaret
Oliver, Clare T
Frost, Debra
Luccarini, Craig
Ahn, Sei-Hyun
Pichert, Gabriella
Davidson, Rosemarie
Chu, Carol
Eccles, Diana
Ong, Kai-Ren
Cook, Jackie
Douglas, Fiona
Hodgson, Shirley
Evans, D Gareth
Eeles, Rosalind
Dork, Thilo
Gold, Bert
Pharoah, Paul D P
Offit, Kenneth
Chenevix-Trench, Georgia
Easton, Douglas F
BCAC/CIMBA
Schürmann, Peter
Karstens, Johann H
Hillemanns, Peter
Couch, Fergus J
Olson, Janet
Vachon, Celine
Wang, Xianshu
Cox, Angela
Brock, Ian
Elliott, Graeme
Reed, Malcolm W R
Burwinkel, Barbara
Meindl, Alfons
Brauch, Hiltrud
Hamann, Ute
Ko, Yon-Dschun
GENICA Network
Broeks, Annegien
Schmidt, Marjanka K
Van 't Veer, Laura J
Braaf, Linde M
Johnson, Nichola
Fletcher, Olivia
Gibson, Lorna
Peto, Julian
Turnbull, Clare
Seal, Sheila
Renwick, Anthony
Rahman, Nazneen
Wu, Pei-Ei
Yu, Jyh-Cherng
Hsiung, Chia-Ni
Shen, Chen-Yang
Southey, Melissa C
Hopper, John L
Hammet, Fleur
Van Dorpe, Thijs
Dieudonne, Anne-Sophie
Hatse, Sigrid
Lambrechts, Diether
Andrulis, Irene L
Bogdanova, Natalia
Antonenkova, Natalia
Rogov, Juri I
Prokofieva, Daria
Bermisheva, Marina
Khusnutdinova, Elza
van Asperen, Christi J
Tollenaar, Robert A E M
Hooning, Maartje J
Devilee, Peter
Margolin, Sara
Lindblom, Annika
Milne, Roger L
Arias, José Ignacio
Zamora, M Pilar
Benítez, Javier
Severi, Gianluca
Baglietto, Laura
Giles, Graham G
kConFab
AOCS Study Group
Spurdle, Amanda B
Beesley, Jonathan
Chen, Xiaoqing
Holland, Helene
Healey, Sue
Wang-Gohrke, Shan
Chang-Claude, Jenny
Mannermaa, Arto
Kosma, Veli-Matti
Kauppinen, Jaana
Kataja, Vesa
Agnarsson, Bjarni A
Caligo, Maria A
Godwin, Andrew K
Nevanlinna, Heli
Heikkinen, Tuomas
Fredericksen, Zachary
Lindor, Noralane
Nathanson, Katherine L
Domchek, Susan M
SWE-BRCA
Loman, Niklas
Karlsson, Per
Stenmark Askmalm, Marie #
Issue Date: 2012
Publisher: Public Library of Sciene
Series Title: PLoS One vol:7 issue:6
Article number: e35706
Abstract: Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.
URI: 
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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