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Title: Polymorphism analysis suggests that the gelatinase B gene is not a susceptibility factor for multiple sclerosis
Authors: Nelissen, Inge ×
Vandenbroeck, K
Fiten, P
Hillert, J
Olsson, T
Marrosu, M G
Opdenakker, Ghislain #
Issue Date: Jun-2000
Series Title: Journal of neuroimmunology vol:105 issue:1 pages:58-63
Abstract: The human gelatinase B (MMP-9) gene promoter region contains a CA microsatellite repeat and a single nucleotide polymorphism which are known to influence transcriptional activity. These two polymorphisms were used to investigate the existence of an association between multiple sclerosis (MS) susceptibility and the MMP-9 gene. In a case-control analysis of 345 Swedish individuals and in a study of 125 Sardinian simplex families no genetic associations between the gelatinase B gene polymorphisms and MS susceptibility were found. These data reinforce the suggestion of epistasis in the regulation of the metalloproteinase-inhibitor balance in MS.
ISSN: 0165-5728
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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