Title: Amyloid precursor protein is trafficked and secreted via synaptic vesicles
Authors: Groemer, Teja W *
Thiel, Cora S *
Holt, Matthew * ×
Riedel, Dietmar
Hua, Yunfeng
Hüve, Jana
Wilhelm, Benjamin G
Klingauf, Jürgen #
Issue Date: Apr-2011
Publisher: Public Library of Sciene
Series Title: PLoS One vol:6 issue:4 pages:1-12
Article number: 10.1371/journal.pone.0018754
Abstract: A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal synaptogenesis and synapse maintenance, as well as in the pathology of Alzheimer's Disease (AD). Although APP processing and release are known to occur in response to neuronal stimulation, the exact mechanism by which APP reaches the neuronal surface is unclear. We now demonstrate that a small but relevant number of synaptic vesicles contain APP, which can be released during neuronal activity, and most likely represent the major exocytic pathway of APP. This novel finding leads us to propose a revised model of presynaptic APP trafficking that reconciles existing knowledge on APP with our present understanding of vesicular release and recycling.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
* (joint) first author
× corresponding author
# (joint) last author

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