Title: Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes
Authors: Ding, L ×
Balzarini, Jan
Schols, Dominique
Meunier, B
De Clercq, Erik #
Issue Date: Oct-1992
Series Title: Biochemical Pharmacology vol:44 issue:8 pages:1675-9
Abstract: A series of cationic metalloporphyrin-ellipticine complexes were found to inhibit the cytopathicity of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus in MT-4 cells at concentrations ranging from 1.4 to 17 micrograms/mL, i.e. at a concentration that was 2.5-30-fold below the cytotoxicity threshold. These compounds were also found to inhibit syncytium formation between persistently HIV-1-infected HUT-78 and uninfected Molt/4 cells, to interfere with HIV-1 binding to the cells, and to suppress HIV-1-associated reverse transcriptase activity.
ISSN: 0006-2952
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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