Title: Synergism between platelet activating factor and C-C chemokines for arachidonate release in human monocytes
Authors: Sozzani, S ×
Rieppi, M
Locati, M
Zhou, D
Bussolino, F
Proost, Paul
Van Damme, Jozef
Mantovani, A #
Issue Date: Mar-1994
Series Title: Biochemical and Biophysical Research Communications vol:199 issue:2 pages:761-6
Abstract: Monocyte Chemotactic Protein(MCP)-1 and other members of the C-C branch of the chemokine superfamily (RANTES, MIP1 alpha/LD78, and MCP-3) induced, at chemotactic concentrations, the release of [3H]arachidonic acid in prelabeled human monocytes. Arachidonate release was potentiated (2 to 4 fold) in the presence of platelet activating factor (PAF). PAF effect was blocked by a specific receptor antagonist, WEB 2187, and was not present when inactive analogs, PAF inactive enantiomer, or lysoPAF were used. Thus, the synergistic action of PAF with C-C chemokines, in terms of arachidonate release and chemotaxis, is specific for this alkylphospholipid and is receptor mediated. Reciprocal potentiation of PAF and C-C chemokines may be important at sites of inflammation.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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