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Title: Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts
Authors: Boraska, Vesna ×
Day-Williams, Aaron
Franklin, Christopher S
Elliott, Katherine S
Panoutsopoulou, Kalliope
Tachmazidou, Ioanna
Albrecht, Eva
Bandinelli, Stefania
Beilin, Lawrence J
Bochud, Murielle
Cadby, Gemma
Ernst, Florian
Evans, David M
Hayward, Caroline
Hicks, Andrew A
Huffman, Jennifer
Huth, Cornelia
James, Alan L
Klopp, Norman
Kolcic, Ivana
Kutalik, Zoltán
Lawlor, Debbie A
Musk, Arthur W
Pehlic, Marina
Pennell, Craig E
Perry, John R B
Peters, Annette
Polasek, Ozren
St Pourcain, Beate
Ring, Susan M
Salvi, Erika
Schipf, Sabine
Staessen, Jan A
Teumer, Alexander
Timpson, Nicholas
Vitart, Veronique
Warrington, Nicole M
Yaghootkar, Hanieh
Zemunik, Tatijana
Zgaga, Lina
Anttila, Verneri
Borecki, Ingrid B
Holmen, Jostein
Ntalla, Ioanna
Palotie, Aarno
Pietiläinen, Kirsi H
Wedenoja, Juho
Winsvold, Bendik S
Dedoussis, George V
Kaprio, Jaakko
Province, Michael A
Zwart, John-Anker
Burnier, Michel
Campbell, Harry
Cusi, Daniele
Smith, George Davey
Frayling, Timothy M
Gieger, Christian
Palmer, Lyle J
Pramstaller, Peter P
Rudan, Igor
Völzke, Henry
Wichmann, H-Erich
Wright, Alan F
Zeggini, Eleftheria #
Issue Date: 2012
Publisher: Public Library of Sciene
Series Title: PLoS One vol:7 issue:3 pages:e31369-e31369
Abstract: Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p<0.05) in the age-adjusted strata for men and across both sexes. In this first GWAS meta-analysis for BC to date, we have not identified any genome-wide significant signals and do not observe robust association of previously established obesity loci with BC. Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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