Title: Cross-sectional and longitudinal assessment of arterial stiffening with age in European and chinese populations
Authors: Wojciechowska, Wiktoria
Stolarz-Skrzypek, Katarzyna
Kawecka-Jaszcz, Kalina
Staessen, Jan A ×
Wang, Ji-Guang
European Project on Genes in Hypertension and the JingNing Study Investigators #
Issue Date: 2012
Publisher: Frontiers Research Foundation
Series Title: Frontiers in Physiology vol:3 pages:209-0
Abstract: As arteries become stiffer with aging, reflected waves move faster and augment late systolic pressure. Few studies have described the age-related changes in both peripheral and central systolic blood pressures in populations. We investigated the age dependency of peripheral (pSBP) and central (cSBP) systolic pressure and pressure amplification (i.e., difference between peripheral and central SBP) in randomly selected participants from European and Chinese populations. Data were collected in 1420 Europeans (mean age, 41.7 years) and 2044 (mean age, 45.1 years) Chinese. In cross-sectional analyses of the population samples cSBP consistently increased more with age than pSBP with the age-related increases being greater in women than men. Repeat assessment of pSBP and cSBP in 398 Europeans and 699 Chinese at a median interval approximately 4 years of follow-up confirmed that also within subjects cSBP rose steeper with aging than pSBP. In conclusion, with aging, pSBP approximates to cSBP. This might explain why in older subjects pSBP becomes the main predictor of cardiovascular complications.
ISSN: 1664-042X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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