Title: Chemo-enzymatic synthesis of 3-deoxy-beta-D-ribofuranosyl purines and study of their biological properties
Authors: Barai, Vladimir N
Zinchenko, Anatoli I
Eroshevskaya, Ludmilla A
Zhernosek, Elena V
Balzarini, Jan
De Clercq, Erik
Mikhailopulo, Igor A #
Issue Date: May-2003
Host Document: Nucleosides, nucleotides & nucleic acids vol:22 issue:5-8 pages:751-3
Conference: XV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications" location:Leuven, Belgium date:10-14 September 2002
Abstract: 9-(3-Deoxy-beta-D-erythro-pentofuranosyl)-2,6-diaminopurine (2) was synthesized by an enzymatic transglycosylation of 2,6-diaminopurine using 3'-deoxycytidine (1) as a donor of the sugar moiety. Nucleoside 2 was transformed to 3'-deoxy guanosine (3), 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-amino-6-oxopurine (3'-deoxyisoguanosine; 4), and 9-(3-deoxy-beta-D-erythro-pentofuranosyl)-2-fluoroadenine (5). Compounds 2-5 were evaluated for their anti-HIV activity.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
# (joint) last author

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