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Title: Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Authors: Bloemen, Maarten ×
Brullot, Ward
Luong, Thien Tai
Geukens, Nick
Gils, Ann
Verbiest, Thierry #
Issue Date: 8-Aug-2012
Publisher: Springer Netherlands
Series Title: Journal of Nanoparticle Research vol:14 issue:9 pages:1-10
Abstract: Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.
ISSN: 1388-0764
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
Chemistry @ Kulak
Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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