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Title: Synthesis of imidazo[1,2-a]pyridine derivatives as antiviral agents
Authors: Mavel, S ×
Renou, J L
Galtier, C
Snoeck, Robert
Andrei, Graciela
Balzarini, Jan
De Clercq, Erik
Gueiffier, A #
Issue Date: Jan-2001
Series Title: Arzneimittel-Forschung vol:51 issue:4 pages:304-9
Abstract: The synthesis and antiviral activity of original dibromoimidazo[1,2-a]pyridines bearing a thioether side chain are reported. Molecular modeling was used to identify biophoric structural patterns that are common to 16 compounds. Structure-activity relationship (SAR) studies identified hydrophobicity (logP) as the most important factor for activity. From these SAR studies, the antiviral activity could be predicted.
ISSN: 0004-4172
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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