Title: Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents
Authors: Rao, Angela ×
Balzarini, Jan
Carbone, Anna
Chimirri, Alba
De Clercq, Erik
Monforte, Anna Maria
Monforte, Pietro
Pannecouque, Christophe
Zappalà, Maria #
Issue Date: Jan-2004
Publisher: Elsevier France, Editions Scientifiques et Medicales
Series Title: Il Farmaco vol:59 issue:1 pages:33-9
Abstract: Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).
ISSN: 0014-827X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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