Title: Coupling Cell Mechanics and Intracellular Signalling: Mechanotransduction through ERK
Authors: Kerkhofs, Johan
Geris, Liesbet
Bosmans, Bart
Van Oosterwyck, Hans
Issue Date: 12-Apr-2012
Publisher: ARUP
Host Document: The Proceedings of the 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering. Hotel Berlin, Berlin, Germany, April 7th – 11th, 2012 pages:0-0
Conference: 10th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering edition:10 location:Berlin date:7-11 April 2012
Article number: CELL086
Abstract: Load-bearing tissues are dependent on mechanical stimuli in their environment to maintain a stable phenotype. Tissue’s basic unit, the cell, must process these stimuli into what constitutes an appropriate response on the tissue level. Here, we present a theoretical model that bridges the gap between mechanical signals and their regulation of intracellular signalling pathways. The model comprises an Ordinary Differential Equations (ODE) model of the ERK signalling pathway, coupled to a 1D rheological model of cell-matrix mechanics. The model predicts markedly different ERK activation for static versus dynamical loading. Furthermore, the model demonstrates the importance of substrate stiffness for ERK signalling. These results show the model’s potential in elucidating mechanotransduction phenomena.
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Biomechanics Section

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