Title: Induction of gelatinase B and MCP-2 in baboons during sublethal and lethal bacteraemia
Authors: Paemen, L ×
Jansen, P M
Proost, Paul
Van Damme, Jozef
Opdenakker, Ghislain
Hack, E
Taylor, F B #
Issue Date: Jun-1997
Series Title: Cytokine vol:9 issue:6 pages:412-5
Abstract: Intravenous injection of sublethal or lethal doses of Escherichia coli in baboons resulted in increased serum levels of the matrix metalloprotease gelatinase B and the chemokine monocyte chemotactic protein 2 (MCP-2). In both animal models, gelatinase B appeared faster than MCP-2. After sublethal challenge, serum levels of gelatinase B and MCP-2 were found to be correlated, reaching peak levels between 2 and 4 h after bacterial challenge. After lethal challenge, however, MCP-2 tended to increase until 10 h. The kinetics of appearance suggest induction of release of gelatinase B and de novo synthesis and secretion of MCP-2, both by endotoxin.
ISSN: 1043-4666
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
Academic Center for General Practice
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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