Title: Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids
Authors: Barbarić, Monika ×
Ursić, Stanko
Pilepić, Viktor
Zorc, Branka
Hergold-Brundić, Antonija
Nagl, Ante
Grdisa, Mira
Pavelić, Kresimir
Snoeck, Robert
Andrei, Graciela
Balzarini, Jan
De Clercq, Erik
Mintas, Mladen #
Issue Date: Feb-2005
Publisher: ACS Publications
Series Title: Journal of Medicinal Chemistry vol:48 issue:3 pages:884-887
Abstract: In vitro evaluation of the novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a-g) demonstrated that 2b,d,e exhibited rather marked inhibitory activity (IC50 = 7-10 microM) against pancreatic carcinoma, 2b-d against colon carcinoma, 2d against laryngeal carcinoma, and 2b,d against breast carcinoma. 2e showed the most pronounced anti-cytomegalovirus activity (EC50 = 1.5 and 0.8 microg mL(-1)) only at > or = 5-fold lower than the cytotoxic concentration. 2d and 2f showed modest, albeit selective, activity against cytomegalovirus (2d, EC50 = 7.3-8.9 microg mL(-1), selectivity index 7-10; 2f, EC50 = 7-13 microg mL(-1), selectivity index 10).
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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