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Title: Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues
Authors: Nieto, M I ×
Blanco, J M
Caamaño, O
Fernández, F
García-Mera, X
Balzarini, Jan
Padalko, E
Neyts, Johan
De Clercq, Erik #
Issue Date: Jul-1998
Series Title: Nucleosides & nucleotides vol:17 issue:7 pages:1255-66
Abstract: Six new carbocyclic nucleosides were prepared by mounting a purine (compounds 5-7), 8-azapurine (compounds 9 and 10) or pyrimidine (compound 13) base on the amino group of (1R,cis)-3-(aminomethyl)-1,2,2-trimethylcyclopentylmethanol (2). The antiviral activity of compounds 5-7, 10 and 13, and their cytostatic activity, were evaluated. At subtoxic concentrations, the compounds showed no or marginal antiviral activity. Compound 5 showed moderate inhibition on tumor cell proliferation.
ISSN: 0732-8311
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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