Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator
Rother, Madlen * Krohn, Stefanie * Kania, Gabriela Vanhoutte, Davy Eisenreich, Andreas Wang, Xiaomin Westermann, Dirk Savvatis, Kostas Dannemann, Nadine Skurk, Carsten Hilfiker-Kleiner, Denise Cathomen, Toni Fechner, Henry Rauch, Ursula Schultheiss, Heinz-Peter Heymans, Stephane Eriksson, Urs Scheibenbogen, Carmen Poller, Wolfgang # ×
Lippincott Williams & Wilkins
Circulation vol:122 issue:25 pages:2688-98
CCN1 is an evolutionary ancient matricellular protein that modulates biological processes associated with tissue repair. Induction at sites of injury was observed in conditions ranging from skin wounds to cardiac diseases, including ischemic and inflammatory cardiomyopathy. Here, we provide evidence of a novel function of CCN1 as a modulator of immune cell migration.