The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation
Vitalone, Matthew J × Naesens, Maarten Sigdel, Tara Hseih, Sue Sarwal, Minnie M #
Lippincott Williams & Wilkins
Transplantation vol:92 issue:7 pages:787-95
Tubulointerstitial damage (TID) is a key feature of chronic allograft injury (CAI) and loss. One proposed mechanism attributing to TID is epithelial-to-mesenchymal transition (EMT); however, it has recently been shown to be unrelated to early TID in adult renal allografts. This has yet to be studied in late TID or in pediatric renal transplantation; both questions were investigated.