Title: Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors
Authors: Zhang, Y ×
Mu, Q
Zhou, H
Vrijens, K
Roussel, M. F
Jiang, G
Yan, Bing #
Issue Date: May-2012
Publisher: Nature Publishing Group
Series Title: Cell Death & Disease vol:3 pages:-
Article number: e308
Abstract: Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1) promotes myogenic differentiation of mouse myoblast cells and inhibits cell apoptosis under the differentiation conditions by regulating basic helix-loop-helix transcription factors. MWCNT 1 attenuates bone morphogenetic protein receptor (BMPR) signaling activity by binding to BMPR2 and attenuating the phosphorylation of BMPR1. This molecular understanding allowed us to tune stem cell differentiation to various levels by chemical modifications, demonstrating human control of biological activities of nanoparticles and opening an avenue for potential applications of nanomaterials in regenerative medicine. Cell Death and Disease (2012) 3, e308; doi:10.1038/cddis.2012.48; published online 10 May 2012
ISSN: 2041-4889
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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