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Title: Ceramide involvement in apoptosis and apoptotic diseases
Authors: Thevissen, Karin ×
Fran├žois, Isabelle
Winderickx, Joris
Pannecouque, Christophe
Cammue, Bruno #
Issue Date: Jun-2006
Series Title: Mini reviews in medicinal chemistry vol:6 issue:6 pages:699-709
Abstract: Apoptosis is implicated in a number of diseases, including neurodegenerative diseases and AIDS. More and more, evidence is accumulating pointing to the critical role of ceramides in the induction of apoptosis. The present review summarizes (i) the molecular basis and regulation of the apoptotic machinery, (ii) the molecular role of ceramides in the induction or execution of apoptotic pathways, and (iii) evidence linking ceramide generation to various apoptotic diseases. Additionally, this review discusses putative therapeutic approaches inhibiting ceramide production in apoptotic diseases.
URI: 
ISSN: 1389-5575
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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