Title: Human tissue-type plasminogen activator gene located near chromosomal breakpoint in myeloproliferative disorder
Authors: Yang-Feng, T L ×
Opdenakker, Ghislain
Volckaert, Guido
Francke, U #
Issue Date: Jul-1986
Series Title: American Journal of Human Genetics vol:39 issue:1 pages:79-87
Abstract: Plasminogen activators (PA) convert the inactive proenzyme plasminogen into plasmin, which is involved in the process of fibrinolysis, tissue remodeling, and cell migration. There are two distinct forms of PA: urokinase (u-PA) and tissue-type plasminogen activator (t-PA). t-PA has higher affinity for fibrin and is the main form involved in thrombolysis. By in situ chromosomal hybridization and Southern blot analysis of somatic cell hybrid DNA, we have assigned the human t-PA gene to chromosome 8, bands 8p12----q11.2. We have detected a common EcoRI restriction fragment length polymorphism within the t-PA gene that thus provides a precisely localized highly informative marker for genetic linkage studies. The t-PA gene localization coincides with a translocation breakpoint observed in myeloproliferative disorders. Whereas leukemic cells usually secrete both types of PA, a correlation exists between acute myeloid leukemic cells that release only t-PA and failure to respond to chemotherapy.
ISSN: 0002-9297
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Division of Gene Technology (-)
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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