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Title: HTLV-negative and HTLV type I-positive tropical spastic paraparesis in northeastern Brazil
Authors: Costa, C M ×
Goubau, Patrick
Liu, H F
Vandamme, Anne-Mieke
da Cunha, F M
Santos, T J
Desmyter, Jan
Carton, Herwig #
Issue Date: Feb-1995
Series Title: AIDS Research and Human Retroviruses vol:11 issue:2 pages:315-8
Abstract: A type-specific serological survey among 1042 random nonneurological outpatients in two cities in the state of Ceara (northeastern Brazil) shows a low prevalence of HTLV-I (0.34% in Fortaleza; 0.44% in Crato) and of HTLV-II (0.34% in Fortaleza; 0% in Crato). Among 62 chronic myelopathic patients seen in Fortaleza 27 patients were found with clinical features of tropical spastic paraparesis (TSP); 10 of 27 were found HTLV-I seropositive (37%; 95% confidence limits, 19-58%). Proviral genome detection by polymerase chain reaction in 5 seropositive and 12 seronegative patients confirmed the serological findings. This excludes HTLV-I or -II infection as a cause in the seronegative TSP patients. The HTLV-positive and -negative patients did not differ clinically and by history, except that seropositives had a longer mean disease duration, a female predominance, and a higher proportion of white Caucasians. In this population with low HTLV-I and HTLV-II prevalences, HTLV-negative TSP is at least as frequent as the HTLV-I-associated TSP.
ISSN: 0889-2229
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical and Epidemiological Virology (Rega Institute)
Research Group Experimental Neurology
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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