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Title: New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity
Authors: D'Atri, Valentina ×
Oliviero, Giorgia
Amato, Jussara
Borbone, Nicola
D'Errico, Stefano
Mayol, Luciano
Piccialli, Vincenzo
Haider, Shozeb
Hoorelbeke, Bart
Balzarini, Jan
Piccialli, Gennaro #
Issue Date: Oct-2012
Publisher: Royal Society of Chemistry
Series Title: Chemical Communications vol:48 issue:76 pages:9516-8
Abstract: This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.
URI: 
ISSN: 1359-7345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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