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Title: Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues
Authors: Zhang, Xinying ×
Amer, Adel
Fan, Xuesen
Balzarini, Jan
Neyts, Johan
De Clercq, Erik
Prichard, Mark
Kern, Earl
Torrence, Paul F #
Issue Date: Jun-2007
Series Title: Bioorganic Chemistry vol:35 issue:3 pages:221-232
Abstract: To develop an understanding of the structure-activity relationships for the inhibition of orthopoxviruses by nucleoside analogues, a variety of novel chemical entities were synthesized. These included a series of pyrimidine 5-hypermodified acyclic nucleoside analogues based upon recently discovered new leads, and some previously unknown "double-headed" or "abbreviated" nucleosides. None of the synthetic products possessed significant activity against two representative orthopoxviruses; namely, vaccinia virus and cowpox virus. They were also devoid of significant activity against a battery of other DNA and RNA viruses. So far as the results with the orthopoxviruses and herpes viruses, the results may point to the necessity for nucleoside analogues 5'-phosphorylation for antiviral efficacy.
URI: 
ISSN: 0045-2068
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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