Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer

De Haas-Kock, Danielle FM; Buijsen, Jeroen; Pijls-Johannesma, Madelon; Lutgens, Ludy; Lammering, Guido; van Mastrigt, Ghislaine APG; De Ruysscher, Dirk; Lambin, Philippe; van der Zee, Jacoba

doi:10.1002/14651858.CD006269.pub2

Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer

Author:

De Haas-Kock, Danielle FM

Buijsen, Jeroen ; Pijls-Johannesma, Madelon ; Lutgens, Ludy ; Lammering, Guido ; van Mastrigt, Ghislaine APG ; De Ruysscher, Dirk ; Lambin, Philippe ; van der Zee, Jacoba

Keywords:

Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Combined Modality Therapy, Humans, Hyperthermia, Induced, Randomized Controlled Trials as Topic, Rectal Neoplasms, Science & Technology, Life Sciences & Biomedicine, Medicine, General & Internal, General & Internal Medicine, TOTAL MESORECTAL EXCISION, QUALITY-OF-LIFE, PREOPERATIVE RADIOTHERAPY, INTERSTITIAL THERMORADIOTHERAPY, ADJUVANT CHEMOTHERAPY, RECURRENCE, RADIOCHEMOTHERAPY, CARCINOMA, RESECTION, SURGERY, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, 32 Biomedical and clinical sciences, 42 Health sciences

Abstract:

Surgery has been the treatment of choice for patients with rectal cancer. For locally advanced cancer results were poor, with high rates of locoregional recurrences and poor overall survival data. Adding (chemo)radiotherapy upfront improved results mainly in locoregional control. Adding hyperthermia to radiotherapy preoperatively might have an equivalent beneficial effect.