Title: Up-date on neuro-immune mechanisms involved in allergic and non-allergic rhinitis
Authors: Van Gerven, Laura ×
Boeckxstaens, Guy
Hellings, Peter #
Issue Date: Sep-2012
Publisher: International Rhinologic Society
Series Title: Rhinology vol:50 issue:3 pages:227-235
Abstract: Non-allergic rhinitis (NAR) is a common disorder, which can be defined as chronic nasal inflammation, independent of systemic IgE-mediated mechanisms. Symptoms of NAR patients mimic those of allergic rhinitis (AR) patients. However, AR patients can easily be diagnosed with skin prick test or allergen-specific IgE measurements in the serum, whereas NAR patients form a heterogeneous group and are difficult to diagnose because of an extensive list of different phenotypes, all varying in severity, underlying etiology and type of inflammation. Characterization of those phenotypes, mechanisms and management of NAR represents one of the major unmet needs in the field of allergic and non-allergic diseases. This review aims at providing a comprehensive overview of the state of the art in classifying the NAR patients and focuses on the neuro-immune mechanisms involved in allergic and non-allergic rhinitis, including reflections on the pathophysiology and the currently available treatment options.
ISSN: 0300-0729
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Immunology
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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