Title: Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives
Authors: Barral, Karine ×
Hider, Robert C
Balzarini, Jan
Neyts, Johan
De Clercq, Erik
Camplo, Michel #
Issue Date: Dec-2003
Series Title: Bioorganic & medicinal chemistry letters vol:13 issue:24 pages:4371-4
Abstract: We describe the synthesis and the antiviral evaluation of novel alpha and beta dideoxynucleoside derivatives in which the base has been replaced by a 3-hydroxy-2-methylpyridin-4-one. The syntheses were successfully achieved by the use of the standard Vorbrüggen coupling conditions. Moderate activity of these compounds were found on herpes simplex virus (HSV) type 1 and type 2.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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