Title: Synthesis and anti-HIV properties of new water-soluble bis-functionalized[60]fullerene derivatives
Authors: Bosi, Susanna ×
Da Ros, Tatiana
Spalluto, Giampiero
Balzarini, Jan
Prato, Maurizio #
Issue Date: Dec-2003
Series Title: Bioorganic & medicinal chemistry letters vol:13 issue:24 pages:4437-40
Abstract: A new series of bis-functionalized fullerene C(60) derivatives bearing two or more solubilizing chains have been evaluated for their activity against HIV-1 and HIV-2 strains. Some of the compounds show activity against HIV-1 type in the low micromolar range. The effect of the positions of the addends on the C(60) nucleus has been investigated, indicating that only trans-2 isomers possess promising activity. The presence of a quaternary pyrrolidinium nitrogen is essential to increase solubility.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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