Title: 1;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines
Authors: Van Roy, N ×
Laureys, G
Cheng, N C
Willem, P
Opdenakker, Ghislain
Versteeg, R
Speleman, F #
Issue Date: Jun-1994
Series Title: Genes, chromosomes & cancer vol:10 issue:2 pages:103-14
Abstract: We report on the finding of a t(1;17) in two primary neuroblastomas. Subsequent fluorescence in situ hybridization (FISH) analysis revealed the presence of 1;17 translocations in four out of nine neuroblastoma cell lines. The chromosome 1 short arm breakpoints were determined using region-specific probes. FISH screening also demonstrated or confirmed the presence of 11;17 translocations in three cell lines and other chromosome 17 rearrangements in those cell lines that did not carry a t(1;17) or t(11;17). Our data extend previous cytogenetic findings and suggest that, in addition to the known involvement of chromosome 1, one or more genes on chromosome 17 also play a role in neuroblastoma development.
ISSN: 1045-2257
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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