Title: 7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase
Authors: Balzarini, Jan ×
Gamboa, A E
Esnouf, R
Liekens, Sandra
Neyts, Johan
De Clercq, Erik
Camarasa, M J
Pérez-Pérez, M J #
Issue Date: Oct-1998
Series Title: FEBS Letters vol:438 issue:1-2 pages:91-5
Abstract: 7-Deazaxanthine (7DX) was identified as a novel inhibitor of thymidine (dThd) phosphorylase (TPase). It inhibited the TPase reaction in a concentration-dependent manner. At 1 mM, it almost completely prevented the TPase-catalysed hydrolysis of dThd to thymine. The 50% inhibitory concentration (IC50 of 7DX was 40 microM in the presence of 100 microM of the natural substrate dThd. 7DX is also endowed with a marked inhibitory effect on angiogenesis. It significantly prevents neovascularisation in the chicken chorioallantoic membrane during development. 7DX is the first purine derivative shown to be a potent inhibitor of purified TPase and angiogenesis.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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