Title: Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action
Authors: Balzarini, Jan ×
Stevens, Miguel
De Clercq, Erik
Schols, Dominique
Pannecouque, Christophe #
Issue Date: Feb-2005
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:55 issue:2 pages:135-138
Abstract: Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave as non-nucleoside reverse transcriptase inhibitors. Other members act, additionally or alternatively, at a post-integrational event in the replication cycle of HIV, that is, at the level of HIV gene expression. Repeated administration of one of the prototype compounds (JPL-32) to DBA/2 and hu-PBMC-SCID mice demonstrated, in the absence of any acute toxicity, protective activity against HIV-induced destruction of CD4 human T lymphocytes.
ISSN: 0305-7453
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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