Title: Muscle atrophy and preferential loss of myosin in prolonged critically ill patients
Authors: Derde, Sarah *
Hermans, Greet *
Derese, Inge
Guiza Grandas, Fabian
Hedström, Yvette
Wouters, Pieter
Bruyninckx, Frans
D'Hoore, André
Larsson, Lars
Van den Berghe, Greet
Vanhorebeek, Ilse # ×
Issue Date: Jan-2012
Publisher: Williams & Wilkins Co.
Series Title: Critical Care Medicine vol:40 issue:1 pages:79-89
Abstract: Muscle weakness contributes to prolonged rehabilitation and adverse outcome of critically ill patients. Distinction between a neurogenic and/or myogenic underlying problem is difficult using routine diagnostic tools. Preferential loss of myosin has been suggested to point to a myogenic component. We evaluated markers of muscle atrophy and denervation, and the myosin/actin ratio in limb and abdominal wall skeletal muscle of prolonged critically ill patients and matched controls in relation to insulin therapy and known risk factors for intensive care unit-acquired weakness.
ISSN: 0090-3493
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Intensive Care Medicine
Abdominal Surgical Oncology
Unit for Clinical-Translational Research (-)
Department of Cellular and Molecular Medicine - miscellaneous
Physical Medicine and Revalidation Section (-)
Laboratory for Clinical Infectious and Inflammatory Disorders
* (joint) first author
× corresponding author
# (joint) last author

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