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Title: Synthesis and in vitro evaluation of novel anti-varicella-zoster virus (VZV) nucleosides
Authors: Carangio, A
McGuigan, C
Cahard, D
Andrei, Graciela
Snoeck, Robert
De Clercq, Erik
Balzarini, Jan #
Issue Date: Apr-2001
Host Document: Nucleosides, nucleotides & nucleic acids vol:20 pages:653-6
Conference: XIV International Round Table on "Nucleosides, Nucleotides and Their Biological Applications" location:San Francisco, CA, USA date:10-14 September 2000
Abstract: A series of alkyl-aryl, -phenoxy, and -thiophenoxy bicyclic furo pyrimidine nucleosides have been successfully synthesised by Pd-coupling of 5-iodo-2'-deoxyuridine (IDU) with terminal alkynes, followed by in situ copper-cyclisation. Synthesised compounds (4a-i) showed an anti-VZV activity at low microM concentration, comparable to that of current treatment acyclovir.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
# (joint) last author

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