Title: Influence of 2-substituent on the activity of imidazo[1,2-alpha] pyridine derivatives against human cytomegalovirus
Authors: Mavel, Sylvie ×
Renou, Jean-Louis
Galtier, Christophe
Allouchi, Hassan
Snoeck, Robert
Andrei, Graciela
De Clercq, Erik
Balzarini, Jan
Gueiffier, Alain #
Issue Date: Apr-2002
Publisher: Pergamon
Series Title: Bioorganic & medicinal chemistry vol:10 issue:4 pages:941-946
Abstract: The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by 1H and 13C NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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