Title: 5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as unique HIV reverse transcriptase inhibitors of S-DABO series
Authors: He, Yanping ×
Chen, Fener
Sun, Guangfu
Wang, Yueping
De Clercq, Erik
Balzarini, Jan
Pannecouque, Christophe #
Issue Date: Jun-2004
Series Title: Bioorganic & medicinal chemistry letters vol:14 issue:12 pages:3173-6
Abstract: The introduction of a beta-carbonyl group to the C-2 side chain of S-DABO led to the finding of a series of novel potent anti-HIV agent. Some derivatives proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentrations. Furthermore, the novel S-DABOs differ from the classical NNRTIs in that some compounds are active against both HIV-1 and HIV-2. They might interfere with another target or at least act on RT in a different way as compared to typical NNRTIs.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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