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Title: A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity
Authors: Guenther, Sven ×
Balzarini, Jan
De Clercq, Erik
Nair, Vasu #
Issue Date: Dec-2002
Series Title: Journal of Medicinal Chemistry vol:45 issue:25 pages:5426-5429
Abstract: (E)-5-(2-Bromovinyl)isodideoxyuridine (BVisoDDU), synthesized on the basis of molecular modeling, is selectively active against HSV-1 (three different strains) but inactive against HSV-2. Unlike BVDU, BVisoDDU is completely resistant to cleavage by thymidine phosphorylase. BVisoDDU is also the first nucleoside analogue lacking OH groups at both the 2'- and 3'-position that shows pronounced activity against HSV-1 replication.
URI: 
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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