Title: Synthesis and biological evaluation of novel 1'-branched and spironucleoside analogues
Authors: Chatgilialoglu, Chryssostomos ×
Ferreri, Carla
Gimisis, Thanasis
Roberti, Marinella
Balzarini, Jan
De Clercq, Erik #
Issue Date: Jan-2004
Series Title: Nucleosides, nucleotides & nucleic acids vol:23 issue:10 pages:1565-81
Abstract: Novel anomeric spironucleosides and 1'-cyano-2',3'-didehydro-2',3'-dideoxyuridine, a structural analogue of known anti-HIV agents, were prepared by nucleophilic addition of organolithium reagents to 1'-cyano-2'-deoxy- and 1'-cyano-2'-deoxy-2'beta-bromo-uridine derivatives, respectively. The yield and distribution of products depended on the reaction conditions, which were studied in detail. Although none of the compounds exhibited antiviral activity, two compounds displayed cytostatic activity against both murine leukemia and human T-lymphocyte cells.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science