Title: Syndecan-syntenin-ALIX regulates the biogenesis of exosomes
Authors: Baietti, Maria Francesca
Zhang, Zhe
Mortier, Eva
Melchior, Aurelie
Degeest, Gisele
Geeraerts, Annelies
Ivarsson, Ylva
Depoortere, Fabienne
Coomans, Christien
Vermeiren, Elke
Zimmermann, Pascale ×
David, Guido
Issue Date: 3-Jun-2012
Publisher: Macmillan Magazines Ltd.
Series Title: Nature Cell Biology vol:14 issue:7 pages:677-685
Abstract: The biogenesis of exosomes, small secreted vesicles involved in signalling processes, remains incompletely understood. Here, we report evidence that the syndecan heparan sulphate proteoglycans and their cytoplasmic adaptor syntenin control the formation of exosomes. Syntenin interacts directly with ALIX through LYPX(n)L motifs, similarly to retroviral proteins, and supports the intraluminal budding of endosomal membranes. Syntenin exosomes depend on the availability of heparan sulphate, syndecans, ALIX and ESCRTs, and impact on the trafficking and confinement of FGF signals. This study identifies a key role for syndecan syntenin ALIX in membrane transport and signalling processes.
ISSN: 1465-7392
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Glycobiology and Developmental Genetics (-)
Department of Human Genetics - miscellaneous
× corresponding author

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